Motilium Tablet 10mg and Suspension 5mg/5ml (Domperidone)
Aspin Pharma (Pvt.) Ltd.DRAP reg. 006526
Prescription required
Aspin Pharma’s own product page says Motilium is to be sold only on prescription. Before dispensing, our pharmacist also checks your heart history and your other medicines, because of the heart-rhythm risk.
Same day or next day in Karachi, Lahore, Islamabad, Rawalpindi for orders confirmed before 6pm. Tracked courier, 2 to 4 working days everywhere else. Delivery Rs 250 in Rawalpindi and Islamabad, Rs 300 everywhere else, cash on delivery. Delivery details
Prices in PKR, checked 23 October 2026.
What Motilium is
Motilium (domperidone, as 10 mg tablets or a 5 mg in 5 ml suspension) is used for nausea and vomiting and for indigestion symptoms, which the leaflet calls the dyspeptic symptom complex (fullness, bloating, belching, upper abdominal pain and heartburn), according to Aspin Pharma’s Pakistani leaflet for Motilium (revised February 2024). Aspin’s own product page says it is to be sold only on prescription, so we dispense it on prescription.
- Motilium tablets are DRAP reg. 006526 (DRAP registry entry); the suspension is DRAP reg. 006527.
- Made by Aspin Pharma in Karachi: Aspin’s product page describes it as an antiemetic and gastroprokinetic (it helps the stomach empty).
- Narrower abroad: the Irish product information for Motilium 10 mg tablets (HPRA) lists only the relief of nausea and vomiting, and the European Medicines Agency’s 2014 review says domperidone is no longer authorised in the EU for conditions such as bloating or heartburn.
- Motilium-V is a different product (domperidone maleate) and is not covered on this page.
- DRAP notifies no price for Motilium: both forms are de-controlled, and the price index has no entry.
What is in it
One active ingredient, domperidone, from the label claims in DRAP’s registry.
| Form | Ingredient | Amount |
|---|---|---|
| Motilium tablet (DRAP reg. 006526) | Ingredient: Domperidone | Amount: 10 mg per film-coated tablet |
| Motilium oral suspension (DRAP reg. 006527) | Ingredient: Domperidone | Amount: 1 mg per ml (5 mg per 5 ml) |
What it is used for
Pakistan’s leaflet lists more uses than Ireland’s or the EU’s, which allow nausea and vomiting only.
| Label | Uses |
|---|---|
| Pakistan, Aspin (2024) | Dyspeptic symptoms linked with slow stomach emptying, reflux or oesophagitis (fullness, feeling full early, a swollen abdomen, upper abdominal pain, bloating, belching, wind, nausea and vomiting, heartburn); nausea and vomiting of functional, organic, infectious or dietary origin; and nausea and vomiting caused by radiotherapy, medicines, or Parkinson’s medicines such as levodopa and bromocriptine. |
| New Zealand, Medsafe | In adults and adolescents aged 12 or over weighing at least 35 kg: dyspeptic symptoms that may be linked with slow stomach emptying, and acute nausea and vomiting. |
| Ireland, HPRA | The relief of the symptoms of nausea and vomiting only. |
How to take it
Take it 15 to 30 minutes before meals, according to Aspin Pharma’s Pakistani leaflet for Motilium (revised February 2024); taken after a meal, it is absorbed more slowly.
- How long: the Pakistani leaflet says treatment for acute nausea and vomiting should usually not go beyond one week, and if nausea and vomiting last longer than a week, see your doctor; for its other uses, the first course is up to four weeks, after which a doctor should reassess the need for it.
- The Irish label says use the lowest effective dose for the shortest time needed, usually no longer than one week; the New Zealand datasheet says long-term use should be avoided.
- Antacids and acid-reducing medicines: the Pakistani leaflet says don’t take them at the same time as Motilium; take Motilium before meals and the antacid after meals.
- Shake the suspension well before use, as the Pakistani leaflet says.
- Children: the Pakistani leaflet says the tablets are unsuitable for adults and adolescents weighing less than 35 kg, the dose for lighter adolescents depends on body weight, and its effectiveness is not established in children under 12 who weigh less than 35 kg. Give it to a child only as a doctor directs.
Who should not take it, or should ask a doctor first
Aspin’s 2024 Pakistani leaflet says it is not recommended for people with heart problems; the Irish and New Zealand labels make them a reason not to take it at all.
| Condition | Pakistan (Aspin, 2024) | Ireland (HPRA) and New Zealand (Medsafe) |
|---|---|---|
| A known long QT interval or other heart conduction problem, heart failure or other heart disease, or low or high potassium or low magnesium | Pakistan (Aspin, 2024): Not recommended | Ireland (HPRA) and New Zealand (Medsafe): Must not take it (both labels) |
| Moderate or severe liver disease | Pakistan (Aspin, 2024): Must not take it | Ireland (HPRA) and New Zealand (Medsafe): Must not take it (both labels) |
| Bleeding, a blockage or a tear in the stomach or gut | Pakistan (Aspin, 2024): Must not take it | Ireland (HPRA) and New Zealand (Medsafe): Must not take it (both labels) |
| A prolactin-producing pituitary tumour (prolactinoma), or an allergy to domperidone | Pakistan (Aspin, 2024): Must not take it | Ireland (HPRA) and New Zealand (Medsafe): Must not take it (both labels) |
| Phaeochromocytoma (an adrenal tumour) | Pakistan (Aspin, 2024): Not listed | Ireland (HPRA) and New Zealand (Medsafe): Ireland: must not take it, because of the risk of severe high blood pressure |
| Children under 12 | Pakistan (Aspin, 2024): Its effectiveness is not established in children under 12 who weigh less than 35 kg | Ireland (HPRA) and New Zealand (Medsafe): New Zealand: must not be used under 12. Ireland: effectiveness not established under 12 |
| Aged over 60 | Pakistan (Aspin, 2024): Consult your doctor before taking it | Ireland (HPRA) and New Zealand (Medsafe): Higher risk of heart-rhythm problems (both labels) |
Severe kidney disease: the Pakistani leaflet says it should be taken less often (once or twice a day), and the dose may need to be lowered.
Other medicines: heart, HIV and antifungal medicines
Some medicines raise domperidone’s levels or add to its effect on the heart rhythm; tell your doctor and our pharmacist everything you take.
| Medicine | What the source says | Source |
|---|---|---|
| Clarithromycin, erythromycin, telithromycin (antibiotics); itraconazole, oral ketoconazole, posaconazole, voriconazole (antifungals); ritonavir, saquinavir, telaprevir (HIV and hepatitis C) | What the source says: Must not be taken with domperidone: they block its breakdown and have been shown to prolong the QT interval. | Source: Pakistan |
| Medicines that prolong the QT interval, e.g. amiodarone, sotalol, quinidine and disopyramide (heart rhythm); haloperidol and pimozide (antipsychotics); citalopram and escitalopram (antidepressants); levofloxacin and moxifloxacin (antibiotics); methadone | What the source says: Pakistan: use with caution. Ireland and New Zealand: must not be taken with domperidone (Ireland excepts apomorphine). | Source: Pakistan; Ireland, 4.3 and 4.5; New Zealand, 4.3 |
| Diltiazem, verapamil (heart and blood pressure) | What the source says: Ireland: not recommended with domperidone. New Zealand: must not be taken with domperidone. | Source: Ireland, 4.5; New Zealand, 4.4 |
| Other HIV protease inhibitors, e.g. indinavir | What the source says: Pakistan: use with caution. New Zealand: must not be taken with domperidone. Ireland: domperidone must not be taken with potent CYP3A4 inhibitors. | Source: Pakistan; Ireland, 4.3; New Zealand |
Pregnancy and breastfeeding
Use it in pregnancy only when the expected benefit justifies it, according to the Pakistani, Irish and New Zealand labels alike.
| Who | What the labels say |
|---|---|
| Pregnancy | Pakistan: there are limited data in pregnant women and the potential risk is unknown, so use it only when justified by the expected benefit. |
| Breastfeeding | Pakistan and New Zealand: breastfeeding is not recommended while taking it. Ireland: it passes into breast milk, effects on the baby’s heart can’t be excluded, so decide with your doctor whether to stop breastfeeding or the medicine. |
Side effects
Headache, diarrhoea and breast changes were the most frequent in clinical trials, according to Aspin Pharma’s Pakistani leaflet for Motilium (revised February 2024).
| Source | Side effects |
|---|---|
| Pakistan, clinical trials (1% or more) | Headache, breast enlargement, diarrhoea, breast tenderness, milky discharge from the breast, missed or irregular periods, rash, depression, sleepiness, anxiety, lower sex drive, itching, weakness, dry mouth. |
| Ireland, common | Dry mouth. |
| Serious (Pakistan and Ireland) | Serious ventricular arrhythmias and sudden cardiac death; fits; involuntary movements (extrapyramidal effects, mainly in babies and infants, Ireland says); severe allergic reactions; difficulty passing urine. |
Driving: the Pakistani leaflet says dizziness and sleepiness have been seen, so don’t drive or use machines until you know how it affects you.
Overdose: the Pakistani leaflet says it has been reported mainly in infants and children, with agitation, drowsiness, fits and abnormal movements. Keep it out of children’s reach.
Checking your pack is genuine
As of 23 October 2026, a search of DRAP’s website found no alert, recall or rapid alert naming Motilium.
- Check that the batch number on the carton matches the batch number on the blister or bottle, and that the pack is sealed.
- The Pakistani leaflet says the tablets come in a box of 60 (3 strips of 20) and the suspension in a 120 ml bottle. If a pack looks different from your last one, ask our pharmacist before taking it.
We buy only from authorised distributors, and check the batch and expiry on every item before it is packed.
Information as of 23 October 2026. DRAP publishes new alerts on dra.gov.pk.
Returns and replacements
Medicines and supplements can’t be returned once they have left our pharmacy.
- Returned medicine can never go back into saleable stock. That is a safety rule, not a commercial one.
- If an item arrives damaged or wrong, tell us on WhatsApp within 24 hours and we replace it. That is us fixing our mistake, not a return.
- Anything that arrives expired or within a month of expiry we replace or refund, your choice, with no time limit.
Frequently asked questions
What is Motilium tablet used for?
Motilium contains domperidone. Aspin Pharma’s Pakistani leaflet lists nausea and vomiting, and indigestion symptoms such as fullness, bloating, belching, upper abdominal pain and heartburn. Ireland and the EU now allow it for nausea and vomiting only. It is dispensed on prescription, and our pharmacist checks your heart history and other medicines first.
What is Motilium suspension used for?
The same uses as the tablets: the suspension contains the same medicine, domperidone, 5 mg in each 5 ml. The Pakistani leaflet says the tablets are unsuitable for adults and adolescents under 35 kg, and the dose for lighter adolescents depends on weight, so a child should take it only as a doctor directs.
What are the side effects of domperidone?
In Aspin’s Pakistani leaflet the most frequent in trials were headache, diarrhoea and breast changes; others include dry mouth, sleepiness and rash. The serious risk is to the heart rhythm: the Irish and New Zealand labels link domperidone with serious ventricular arrhythmias and sudden cardiac death, more so over 60 and above 30 mg a day.
Can I take Motilium in pregnancy?
Only if your doctor decides the benefit justifies it: the Pakistani leaflet says the potential risk in pregnancy is unknown. It also says breastfeeding is not recommended while taking Motilium.
Can I take Motilium after eating?
The Pakistani leaflet says take it 15 to 30 minutes before meals; taken after a meal, it is absorbed more slowly.
Does Motilium make you sleepy?
It can. The Pakistani leaflet lists sleepiness and dizziness, and says don’t drive or use machines until you know how it affects you.
Related products
Risek Capsules 20mg and 40mg
Prescription required
20mg, 7 capsules
In stock
Rs 203
See Risek
No-Spa and No-Spa Forte Tablets (Drotaverine)
40mg, 24 tablets
In stock
Rs 247
See No-Spa
Ulsanic Tablet 500mg and 1g, Suspension 1g/5ml (Sucralfate)
Prescription required
500mg, 20 tablets
In stock
Rs 160
See Ulsanic
Zopent Tablet 40mg and 20mg (Pantoprazole)
We dispense this on prescription
40mg, 20 tablets
In stock
Rs 855
See Zopent
Nexum Capsule 20mg and 40mg (Esomeprazole)
Prescription required
20mg, 14 capsules
In stock
Rs 395
See Nexum
Colofac Tablet 135mg (Mebeverine)
We dispense this on prescription
135mg, 30 tablets
In stock
Rs 590
See Colofac
Questions about Motilium Tablet 10mg and Suspension 5mg/5ml (Domperidone)?
Send your question on WhatsApp and a pharmacist will come back to you.
Written by the ePharmacyy pharmacy team.
Last checked against the sources below on
DRAP registration
- Motilium Tablets (006526), Aspin Pharma (Pvt.) Ltd. DRAP’s registry shows: Reviewed, “Not Verified”.
- Motilium Oral Suspension (006527), Aspin Pharma (Pvt.) Ltd. DRAP’s registry shows: Reviewed, “Not Verified”.
DRAP publishes no definition of this verification flag, so we can’t tell you what it means. We searched DRAP’s website for “Motilium”, “Aspin” and “domperidone” on 23 October 2026 and found no alert naming Motilium; the domperidone results were recalls of other companies’ brands. When we tested it, the search did not find a word that appears only inside an alert’s attached PDF, so an alert that names a product only in its PDF may not show up. DRAP describes its registered products index as a provisional list that “cannot be used as a reference for any purpose”. Checked against the registry on .
Sources
- DRAP registered products: Motilium Tablets, registration 006526
- DRAP registered products: Motilium Oral Suspension, registration 006527
- DRAP notified price index (no entry for Motilium or domperidone)
- Aspin Pharma: Motilium product page
- Aspin Pharma: Motilium film-coated tablet / suspension, Pakistani prescribing information (revision date February 2024)
- HPRA (Ireland): Motilium Rx 10 mg film-coated tablets, summary of product characteristics (revised January 2026)
- HPRA (Ireland): Motilium Rx 10 mg, product record and legal supply status
- Medsafe (New Zealand): Motilium datasheet (revised February 2025)
- European Medicines Agency: domperidone-containing medicines, referral outcome (2014)