Colofac Tablet 135mg (Mebeverine)
Abbott Laboratories (Pakistan) LtdDRAP reg. 006652
We dispense this on prescription
We accept a prescription from any registered doctor in Pakistan.
Same day or next day in Karachi, Lahore, Islamabad, Rawalpindi for orders confirmed before 6pm. Tracked courier, 2 to 4 working days everywhere else. Delivery Rs 250 in Rawalpindi and Islamabad, Rs 300 everywhere else, cash on delivery. Delivery details
Prices in PKR, checked 23 October 2026.
What Colofac is
Colofac (mebeverine hydrochloride 135 mg) is an antispasmodic that acts directly on the muscle of the gut, used for the symptoms of irritable bowel syndrome (IBS) such as cramping abdominal pain, persistent diarrhoea with or without constipation, and wind, according to the UK product information for Colofac 135 mg tablets. We dispense it on prescription.
- Colofac 135mg is DRAP reg. 006652 (DRAP registry entry), a tablet of mebeverine hydrochloride 135 mg in packs of 30. DRAP’s registry lists Highnoon Laboratories, Lahore, as its contract manufacturer.
- We found no Pakistani leaflet for Colofac online, so no Pakistani document we could find states its uses or condition of sale. Dispensing it on prescription is our own policy, and the clinical facts on this page come from UK sources, each named where it is used.
- See a doctor if your symptoms are new or getting worse: the UK patient leaflet for Colofac says to check with your doctor or pharmacist before taking it in that case.
- DRAP notifies no price for Colofac: the tablet is de-controlled, and the price index has no entry.
What is in each tablet
One active ingredient, mebeverine hydrochloride, from the label claim in DRAP’s registry.
| Tablet | Ingredient | Amount per tablet |
|---|---|---|
| Colofac 135mg (DRAP reg. 006652) | Ingredient: Mebeverine hydrochloride | Amount per tablet: 135 mg |
The UK Colofac tablets contain lactose and sucrose (types of sugar).
What it is used for
Irritable bowel syndrome and similar bowel problems, and the cramping pain that comes with them.
| Source | Uses |
|---|---|
| UK, Colofac 135 mg | Symptoms of irritable bowel syndrome and related conditions (chronic irritable colon, spastic constipation, mucous colitis, spastic colitis), such as cramping abdominal pain, persistent diarrhoea with or without constipation, and wind. |
| NHS, mebeverine | Stomach cramps, spasms and pain, including in irritable bowel syndrome (IBS). |
How to take it
Three times a day, preferably 20 minutes before meals, according to the UK product information for Colofac 135 mg tablets.
- The UK patient leaflet says swallow the tablet whole with water and don’t chew it; some people find their symptoms strongest after eating, which is why it is taken before a meal.
- How long: the UK label says the length of use is not limited, and that once it has worked, after several weeks, the dose may be reduced gradually. Take it as your prescriber directs.
- Missed dose: the UK patient leaflet says take it as soon as you remember, but if the next dose is nearly due, skip the missed one; don’t take a double dose.
- Food and alcohol: the NHS says you can eat and drink as normal, and the UK patient leaflet says you can drink alcohol while taking it.
Colofac vs Buscopan
Both are antispasmodics that relax the gut muscle and ease cramps, but they are different medicines: Colofac is mebeverine and Buscopan is hyoscine butylbromide. The NHS says mebeverine works in a similar way to Buscopan, and says not to take Buscopan at the same time as other IBS remedies.
| Colofac (mebeverine) | Buscopan (hyoscine butylbromide) | |
|---|---|---|
| How it works | Colofac (mebeverine): UK label: acts directly on the smooth muscle of the gut without affecting normal gut movement; its exact mechanism is not known, and the systemic side effects seen with typical anticholinergic medicines are absent. | Buscopan (hyoscine butylbromide): UK label: relaxes the smooth muscle of the gut, bile ducts and urinary tract; its anticholinergic action comes from blocking nerve ganglia in the walls of these organs and from antimuscarinic activity. |
| Used for | Colofac (mebeverine): Irritable bowel syndrome and similar bowel problems. | Buscopan (hyoscine butylbromide): Spasm of the gut or the urinary tract, and irritable bowel syndrome. |
| Who must not take it (UK labels) | Colofac (mebeverine): Anyone allergic to it. A UK generic leaflet (Teva) adds paralytic ileus. | Buscopan (hyoscine butylbromide): Anyone with myasthenia gravis, a narrowed or blocked bowel (including paralytic ileus), a very enlarged bowel (megacolon) or narrow-angle glaucoma. |
| Side effects | Colofac (mebeverine): Allergic reactions, mainly of the skin; the UK label says their frequency cannot be estimated. | Buscopan (hyoscine butylbromide): Uncommon: dry mouth and a fast heartbeat; rare: difficulty passing urine. |
| Driving | Colofac (mebeverine): Not expected to affect driving. | Buscopan (hyoscine butylbromide): Don’t drive if your vision is affected. |
Which one suits your symptoms is a question for your doctor or our pharmacist. Don’t take them together unless a doctor has told you to.
Who should not take it, or should ask a doctor first
The UK Colofac label’s only formal contraindication is allergy, and it also says people with certain rare inherited sugar intolerances should not take it; other UK sources add more, each named below.
- Must not take it: anyone allergic to mebeverine or any ingredient (UK Colofac label).
- Paralytic ileus (when part of the gut stops working): the UK leaflet for Teva’s mebeverine 135 mg says do not take it, and the NHS says it may not be suitable.
- Acute porphyria: the Teva leaflet says talk to your doctor first.
- Liver or kidney problems: the UK Colofac patient leaflet says check with your doctor or pharmacist first.
- Rare sugar intolerances: the UK label says people with hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency or sucrase-isomaltase insufficiency should not take it, because the tablets contain lactose and sucrose.
- Children: the UK Colofac label does not recommend it under 18, for lack of data; the NHS says most adults and children aged 10 or over can take mebeverine. Ask a doctor before giving it to anyone under 18.
- Other medicines: the UK Colofac patient leaflet says no interactions with other medicines are known.
Pregnancy and breastfeeding
The UK label and the NHS disagree, so both are shown.
| Who | What the sources say |
|---|---|
| Pregnancy | UK Colofac label: not recommended in pregnancy. NHS: you may be able to take it if the benefits outweigh the risks. |
| Breastfeeding | UK Colofac label: it should not be used during breastfeeding. NHS: you can usually take it while breastfeeding, but check with a pharmacist or doctor first. |
Side effects
Allergic reactions, mainly of the skin, are the side effects the UK product information for Colofac 135 mg tablets lists.
| Source | Side effects |
|---|---|
| NHS | A skin rash, or itchy or red skin. |
| UK Colofac patient leaflet, serious | Difficulty breathing, or swelling of the face, neck, tongue or throat (a severe allergic reaction): stop taking the tablets and see a doctor at once. |
Driving: the UK label says nothing indicates that mebeverine affects driving or using machines.
Checking your pack is genuine
As of 23 October 2026, a search of DRAP’s website found no alert, recall or rapid alert naming Colofac.
- Check that the batch number on the carton matches the batch number on the blister inside, and that the pack is sealed.
- If a pack looks different from your last one, ask our pharmacist before taking it.
We buy only from authorised distributors, and check the batch and expiry on every item before it is packed.
Information as of 23 October 2026. DRAP publishes new alerts on dra.gov.pk.
Returns and replacements
Medicines and supplements can’t be returned once they have left our pharmacy.
- Returned medicine can never go back into saleable stock. That is a safety rule, not a commercial one.
- If an item arrives damaged or wrong, tell us on WhatsApp within 24 hours and we replace it. That is us fixing our mistake, not a return.
- Anything that arrives expired or within a month of expiry we replace or refund, your choice, with no time limit.
Frequently asked questions
What is Colofac tablet used for?
Colofac contains mebeverine, an antispasmodic. The UK label for Colofac 135 mg lists the symptoms of irritable bowel syndrome and related conditions, such as cramping abdominal pain, persistent diarrhoea with or without constipation, and wind. We dispense it on prescription.
What is the difference between Colofac and Buscopan?
Both are antispasmodics that relax the gut muscle, but they are different medicines. Colofac is mebeverine, which the UK label says acts directly on gut muscle, by a mechanism not exactly known, without the systemic side effects of typical anticholinergics; Buscopan is hyoscine butylbromide, which its UK label says works through a peripheral anticholinergic action. Buscopan has more reasons not to take it, including glaucoma and myasthenia gravis. The NHS says not to take Buscopan at the same time as other IBS remedies.
What are the side effects of mebeverine?
The NHS lists a skin rash, or itchy or red skin. A severe allergic reaction can cause difficulty breathing or swelling of the face, neck, tongue or throat: the UK patient leaflet says stop taking it and see a doctor at once.
How to take Mebeverine?
The UK label for Colofac 135 mg says three times a day, preferably 20 minutes before meals, and the patient leaflet says swallow it whole with water without chewing. Take it as your prescriber directs.
Is it safe to use during pregnancy?
The UK Colofac label says mebeverine is not recommended in pregnancy, while the NHS says you may be able to take it if the benefits outweigh the risks. Ask your doctor.
Will I have to avoid eating certain foods during use of this medicine?
No. The NHS says you can eat and drink as normal while taking mebeverine.
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Questions about Colofac Tablet 135mg (Mebeverine)?
Send your question on WhatsApp and a pharmacist will come back to you.
Written by the ePharmacyy pharmacy team.
Last checked against the sources below on
DRAP registration
- Colofac 135mg Tablets (006652), Abbott Laboratories (Pakistan) Limited. DRAP’s registry shows: Provisionally Active, “Not Verified”.
DRAP publishes no definition of this verification flag, so we can’t tell you what it means. We searched DRAP’s website for “Colofac”, “mebeverine” and “Buscopan” on 23 October 2026 and found no alert naming Colofac, mebeverine or Buscopan. When we tested it, the search did not find a word that appears only inside an alert’s attached PDF, so an alert that names a product only in its PDF may not show up. DRAP describes its registered products index as a provisional list that “cannot be used as a reference for any purpose”. Checked against the registry on .
Sources
- DRAP registered products: Colofac 135mg Tablets, registration 006652
- DRAP notified price index (no entry for Colofac or mebeverine)
- emc (UK): Colofac 135 mg coated tablets, Cooper Consumer Health, summary of product characteristics (revised June 2025)
- emc (UK): Colofac Tablets 135 mg, patient information leaflet (revised July 2025)
- Teva UK: Mebeverine 135 mg Tablets, patient information leaflet (revised May 2025)
- NHS: Mebeverine
- emc (UK): Buscopan 10 mg Tablets, Opella, summary of product characteristics (revised 22 September 2025)
- NHS: Buscopan (hyoscine butylbromide)
- NHS: Common questions about Buscopan