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Primolut N Tablets 5mg (Norethisterone)

OBS Pharma (Pvt) LtdDRAP reg. 000677

Prescription required

It is a hormone that must not be taken by anyone at high risk of blood clots, so a doctor needs to take your medical history first. We accept a prescription from any registered doctor in Pakistan.

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Same day or next day in Karachi, Lahore, Islamabad, Rawalpindi for orders confirmed before 6pm. Tracked courier, 2 to 4 working days everywhere else. Delivery Rs 250 in Rawalpindi and Islamabad, Rs 300 everywhere else, cash on delivery. Delivery details

Prices in PKR, checked 14 October 2026.

What Primolut N is

A hormone tablet containing norethisterone 5 mg, a progestogen.

  • Registered with DRAP under number 000677. Registered 12 November 1976; DRAP’s product index lookup for 000677 gives OBS Pharma (Pvt) Ltd, Lahore, as the registration holder (DRAP product index; the registry entry itself does not show the holder).
  • Pharmacy listings still name Bayer (for example). VIS Credit Rating reports that OBS Pharma was set up to buy brands and a factory from Bayer AG, under an agreement of 21 November 2022, and names Primolut N among them. DRAP’s record shows no transfer entry.
  • The UK prescribing information on this page is Bayer’s, for the UK product. It is the best available source, not the Pakistani label.
  • DRAP’s notified price for the pack of 30 (3 strips of 10) is Rs 380.13, effective 1 July 2024 (DRAP price index). That is our price.
  • Prescription: OBS Pharma’s own product listing says “To be sold on prescription only.” That is the maker’s web listing; OBS’s insert is not published online. We dispense it on prescription: it is a hormone with blood-clot contraindications, and a doctor needs to take your history before you start.

What is in each tablet

One active ingredient, from the label claim in DRAP’s registry: “Each tablet contains: Norethisterone....5mg”.

Primolut N active ingredient per tablet
Active ingredientPer tablet
Norethisterone5 mg

What it is used for

The UK prescribing information for Primolut N (Bayer plc, revised 13 December 2018) lists six uses, all for periods and the womb.

Uses of Primolut N, from the UK prescribing information
UseIn plain language
Postponement of menstruationDelaying a period.
MenorrhagiaHeavy periods.
Metropathia haemorrhagicaHeavy, irregular bleeding from the womb.
DysmenorrhoeaPainful periods.
Premenstrual syndromeSymptoms in the days before a period.
EndometriosisTissue like the womb lining growing outside the womb.

Bringing on a late or missed period is not one of its listed uses. The same document says that if bleeding does not follow a course, pregnancy must be ruled out before another.

Part of it turns into an estrogen: why blood clots matter

The UK prescribing information says: “After oral administration, norethisterone is partly metabolised to ethinylestradiol resulting in an equivalent dose of about 4-6 micrograms ethinylestradiol per 1 milligram of orally administered norethisterone or norethisterone acetate.”

  • Warning: Ethinylestradiol is the estrogen in most combined contraceptive pills. The same document: “administration of Primolut N is expected to result in similar pharmacological effects as seen with COCs” (combined oral contraceptives).
  • Warning: So the blood-clot warnings people know from the combined pill apply here too. The document tells prescribers to consider the combined pill’s general warnings, including that a clot in a vein “may be life-threatening or may have a fatal outcome (in 1-2 % of the cases).”
  • Warning: Stop taking it and get medical help at once for: pain or swelling in one leg; sudden breathlessness or chest pain; a first migraine or an unusually bad headache; sudden changes in sight or hearing (UK prescribing information and patient leaflet).
  • It should also be stopped six weeks before a planned operation (“Pending operations (six weeks beforehand)”), and if you are immobilised, for example after an accident (UK prescribing information).

Who must not take it

The UK prescribing information for Primolut N (Bayer plc, revised 13 December 2018) says it “should not be used in the presence of any of the conditions listed below”, and that if one appears during use, “the use of the product should be stopped immediately”.

Contraindications of Primolut N, from the UK prescribing information, in plain language
In the prescribing informationWhat it means
Known or suspected pregnancyYou are pregnant, or might be.
LactationYou are breastfeeding.
Previous idiopathic or current venous thromboembolism (deep vein thrombosis, pulmonary embolism)You have a blood clot in a vein or the lungs now, or had one in the past without a clear cause.
Active or recent arterial thromboembolic disease (e.g. angina, myocardial infarction)You have, or recently had, a clot in an artery, such as a heart attack or angina.
Presence or a history of prodromi of a thrombosis (e.g. transient ischaemic attack, angina pectoris)You have had warning signs of a clot, such as a mini-stroke or angina.
A high risk of venous or arterial thrombosisAnything else that puts you at high risk of blood clots.
History of migraine with focal neurological symptomsMigraines with aura, such as vision changes, numbness or speech problems.
Diabetes mellitus with vascular involvementDiabetes that has damaged your blood vessels.
Presence or history of severe hepatic disease as long as liver function values have not returned to normalSevere liver disease, now or before, until liver tests are back to normal.
Previous or existing liver tumours (benign or malignant)A liver tumour, now or before, cancerous or not.
Known, past or suspected sex hormone-dependent malignancies, including of the genital organs or breast cancerA hormone-sensitive cancer, such as breast cancer or cancer of the womb or ovaries, now, before or suspected.
History during pregnancy of idiopathic jaundice or severe pruritusJaundice or severe itching during a past pregnancy.
Undiagnosed genital bleedingVaginal bleeding a doctor has not yet explained.
Untreated endometrial hyperplasiaThickening of the womb lining that has not been treated.
Hypersensitivity to the active substance or any excipientAn allergy to norethisterone or any ingredient. The UK tablet contains lactose.
Hepatitis C medicines ombitasvir, paritaprevir and ritonavir, with dasabuvirYou are taking this hepatitis C combination.

What regulators have and have not reviewed

Searches of the UK MHRA’s and Health Canada’s safety publications (16 October 2026) found no safety communication on norethisterone tablets like Primolut N.

  • The MHRA’s February 2014 review of blood-clot risk covered combined hormonal contraceptives only, following a European review. It names norethisterone only as an ingredient of combined pills, and does not cover Primolut N.
  • That means the UK prescribing information is the best source available. It does not mean Primolut N has been reviewed and cleared.
  • In the UK, Primolut N is a prescription-only medicine (medicines.org.uk).

Tell your doctor first

Conditions the UK prescribing information for Primolut N (Bayer plc, revised 13 December 2018) says need care or monitoring.

  • Diabetes: it can affect blood sugar, which should be checked before and during treatment.
  • A history of depression: it should be stopped if depression returns seriously.
  • Epilepsy, migraine, asthma, or heart or kidney problems: it can cause fluid retention.
  • A significant rise in blood pressure is a reason to stop it.
  • Hereditary angioedema: estrogens may trigger or worsen swelling attacks.
  • Rarely, liver tumours have been reported with hormones like this one. Severe pain in the upper stomach needs a doctor’s check.
  • Warning: Rare inherited sugar problems (galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption): the UK tablet contains lactose, and the UK prescribing information says these patients “should not take this medicine”.

Other medicines

From the UK prescribing information for Primolut N (Bayer plc, revised 13 December 2018), section 4.5. Tell the prescriber everything you take, including herbal remedies.

Medicines that interact with Primolut N, from the UK prescribing information
MedicineWhat happens
Hepatitis C medicines ombitasvir, paritaprevir and ritonavir, with dasabuvirMust not be taken together: raised risk of liver enzyme (ALT) rises.
Phenytoin, barbiturates, primidone, carbamazepine, rifampicin, bosentan; the HIV medicines ritonavir, nevirapine and efavirenz; possibly oxcarbazepine, topiramate, felbamate, griseofulvin and St John’s wortCan change the bleeding pattern or reduce its effect. The effect can last about 4 weeks after stopping them.
Other HIV and hepatitis C medicinesCan raise or lower norethisterone levels.
Azole antifungals (itraconazole, voriconazole, fluconazole), verapamil, diltiazem, macrolide antibiotics (clarithromycin, erythromycin), grapefruit juiceCan raise norethisterone levels; how much this matters is unknown.
CiclosporinIts levels may rise.
LamotrigineIts levels may fall.
Theophylline, tizanidineTheir levels may rise.

It can also affect some blood tests, including liver, thyroid and clotting tests.

Side effects

From the UK prescribing information for Primolut N (Bayer plc, revised 13 December 2018). Its frequencies come from reports after approval and from the medical literature.

Side effects of Primolut N, from the UK prescribing information
How oftenSide effects
Very commonBleeding or spotting from the womb, and lighter periods (in endometriosis treatment).
CommonHeadache, nausea, fluid retention (swelling); no periods (in endometriosis treatment).
UncommonMigraine.
RareAllergic reactions, hives, rash.
Very rareChanges in vision; breathlessness.
Not knownDizziness, worsening depression, stomach pain, slowed bile flow from the liver (cholestasis), jaundice.

Driving: the UK prescribing information lists no known effect on driving or using machines.

Checking your pack is genuine

Our search of DRAP’s website on 14 October 2026 found no alert, recall or rapid alert naming Primolut N or norethisterone.

We buy only from authorised distributors, and check the batch and expiry on every item before it is packed.

Information as of 14 October 2026. DRAP publishes new alerts on dra.gov.pk.

Returns and replacements

Medicines and supplements can’t be returned once they have left our pharmacy.

  • Returned medicine can never go back into saleable stock. That is a safety rule, not a commercial one.
  • If an item arrives damaged or wrong, tell us on WhatsApp within 24 hours and we replace it. That is us fixing our mistake, not a return.
  • Anything that arrives expired or within a month of expiry we replace or refund, your choice, with no time limit.

Our returns policy

Frequently asked questions

Is Primolut used to get periods?

Bringing on a late or missed period is not one of the uses in the UK prescribing information for Primolut N (Bayer plc). A late period can mean pregnancy, and Primolut N must not be taken if you are pregnant or might be: take a pregnancy test and see a doctor first.

What is norethisterone used for?

Norethisterone is a progestogen hormone. The UK prescribing information for Primolut N (Bayer plc) lists delaying a period, heavy periods, heavy irregular bleeding from the womb, painful periods, premenstrual syndrome and endometriosis. Primolut N is not a contraceptive.

Can norethisterone stop periods?

It can delay a period: “postponement of menstruation” is one of its UK uses, and the NHS Specialist Pharmacy Service says norethisterone is the only progestogen licensed in the UK to delay periods. It is not a contraceptive, so it does not protect against pregnancy while you take it. How and for how long is your doctor’s decision.

What are the side effects of Primolut?

The UK prescribing information for Primolut N (Bayer plc) lists headache, nausea and fluid retention as common, and bleeding or spotting as very common in endometriosis treatment. Less often: migraine, allergic reactions, rash, changes in vision and breathlessness. Because part of it turns into an estrogen, the blood-clot warnings of the combined pill also apply.

What are the common side effects of norethisterone?

In the UK prescribing information for Primolut N (Bayer plc), the common side effects are headache, nausea and fluid retention (swelling). In endometriosis treatment, spotting and lighter periods are very common, and no periods at all is common.

Is Primolut-N safe to take?

Not for everyone. The UK prescribing information for Primolut N (Bayer plc) says it must not be taken in pregnancy or while breastfeeding, or by anyone who has had a blood clot without a clear cause, has a high risk of clots, has active or recent clot disease in an artery such as angina or a heart attack, has or has had warning signs of a clot such as a mini-stroke, has migraines with aura, has severe liver disease or a liver tumour, or has a hormone-sensitive cancer. Part of it turns into an estrogen, so the combined pill’s blood-clot warnings apply. That is why we dispense it only on prescription.

How many days should I take Primolut-N tablets?

It depends on what a doctor is treating. The UK prescribing information for Primolut N (Bayer plc) gives different courses for six uses: heavy irregular bleeding from the womb, premenstrual syndrome, postponing a period, endometriosis, heavy periods and painful periods. Which one applies depends on a doctor’s diagnosis, so the length of the course is for your prescriber. That is why the number isn’t on our page: taking a hormone for the wrong length of time, without a doctor, is the risk we want you to avoid.

When is the best time to take Primolut N?

The UK prescribing information gives no time of day; the tablets are swallowed whole with some liquid. When in your cycle to start depends on what it is being used for, and that differs between its uses, so your prescriber sets it.

Can Primolut-N tablets stop periods immediately?

No. Postponing a period is one of its uses in the UK prescribing information, but that course starts before the period is due; the prescribing information describes no use for stopping a period that has already started. For heavy, irregular bleeding from the womb, a condition a doctor diagnoses, it says “Bleeding is arrested usually within 1-3 days.”

How fast does Primolut work?

It depends on the use. For heavy, irregular bleeding from the womb, the UK prescribing information says “Bleeding is arrested usually within 1-3 days.” When a course ends, bleeding like a normal period follows: within 2 to 4 days after that course, and 2 to 3 days after a course to postpone a period. For its other uses it gives no figure.

Which tablet is used to get periods in 5 days?

Primolut N is not what this question is looking for. Bringing on a period is not one of the uses in Primolut N’s UK prescribing information. If your period is late and you could be pregnant, take a pregnancy test and see a doctor before taking anything.

Questions about Primolut N Tablets 5mg (Norethisterone)?

Send your question on WhatsApp and a pharmacist will come back to you.

DRAP registration

  • Primolut N Tablets (000677), OBS Pharma (Pvt) Ltd. DRAP’s registry shows: Reviewed, “Not Verified”.

DRAP publishes no definition of this verification flag, so we can’t tell you what it means. We searched DRAP’s website for “Primolut” and “norethisterone” on 16 October 2026 and found no alert naming Primolut N or norethisterone. When we tested it, the search did not find a word that appears only inside an alert’s attached PDF, so an alert that names a product only in its PDF may not show up. DRAP describes its registered products index as a provisional list that “cannot be used as a reference for any purpose”. Checked against the registry on .

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